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KMID : 0361020220650100610
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Korean Journal of Otolaryngology - Head and Neck Surgery
2022 Volume.65 No. 10 p.610 ~ p.616
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Neoadjuvant Immunotherapy Following Definitive Surgical Treatment for Locoregionally Advanced Head and Neck Cancer: Perioperative Complication and Surgical Outcomes
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Park Ju-Ha
Park Young-Min
Kim Da-Hee
Kim Se-Hun
Kim Hye-Ryun
Koh Yoon-Woo
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Abstract
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Background and Objectives : We analyzed surgical outcomes, perioperative complications,and mortality in head and neck squamous cell carcinoma (HNSCC) in patients who underwentcurative surgery following neoadjuvant immunotherapy.
Subjects and Method : The records of 36 HNSCC patients who underwent curative surgerywith neoadjuvant immunotherapy and 69 HNSCC patients who received neoadjuvant chemotherapywere analyzed.
Results : The average operation time was 315 minutes, and the average bleeding volume was167 cc. The average length of hospital stay was 21 days. When evaluating surgical margin status,we found 24 patients (66.6%) who exhibited a negative margin. We found no case wheresurgery was impossible due to progression of the lesion during neoadjuvant immunotherapy. Compared to the neoadjuvant chemotherapy group, neoadjuvant immunotherapy group showedacceptable perioperative safety and complication profile. The postoperative complication ratewas 19.4% in the neoadjuvant immunotherapy group and 13.0% in the neoadjuvant chemotherapygroup (p=0.386). There were no serious complications during the recovery period aftersurgery or instances of death due to complications.
Conclusion : In HNSCC patients, there was no increase in the incidence of complications ormortality related to curative surgery after neoadjuvant immunotherapy.
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KEYWORD
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Chemotherapy, Immunotherapy, Neoadjuvant therapy, Postoperative complications
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